B
bizorky
Guest
^I'm trying to think of film directors' who made the claim that the studio took the film from them and recut it.
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S
scarberiankhatru
Guest
"Maybe you missed that part."
I was only ten when all this went down...I was five back when Bernardo was just the Scarborough rapist, but I remember that a lot better because one incident took place about two blocks from my house - it was like the first crime ever in my neighbourhood.
"I'm trying to think of film directors' who made the claim that the studio took the film from them and recut it."
Orson Welles with The Magnificent Ambersons - he knew that they were recutting it but he was shooting a documentary in Brazil and couldn't stop them. Touch of Evil was also recut by the studio.
I was only ten when all this went down...I was five back when Bernardo was just the Scarborough rapist, but I remember that a lot better because one incident took place about two blocks from my house - it was like the first crime ever in my neighbourhood.
"I'm trying to think of film directors' who made the claim that the studio took the film from them and recut it."
Orson Welles with The Magnificent Ambersons - he knew that they were recutting it but he was shooting a documentary in Brazil and couldn't stop them. Touch of Evil was also recut by the studio.
B
bizorky
Guest
^I was trying to make a joke about bad films which directors blamed on the studios.
I am sure that there have been people who have never gone to prison because they have successfully claimed to be victims of some external circumstance, which was the cause of their own criminal activity.
I am sure that there have been people who have never gone to prison because they have successfully claimed to be victims of some external circumstance, which was the cause of their own criminal activity.
G
geo8
Guest
Halting drug can stop compulsive gambling in Parkinson's patients: study
11/07/2005 6:58:00 PM
TORONTO (CP) - A clergyman who rarely visits a casino suddenly becomes a compulsive gambler and starts bleeding his bank account dry. Another man becomes so aroused that he chases his wife around the house demanding sex.
What do these two men have in common? They both developed addictive behaviours after taking a particular type of drug to treat Parkinson's disease, say researchers at the Mayo Clinic in Rochester, Minn.
And the study found that patients completely lost the compulsive behaviour after stopping the drug.
"One patient said it was like a light switch going off," said Dr. Leann Dodd, a Mayo Clinic psychiatrist and co-author of the study published in the Archives of Neurology.
The study reports on two women and nine men with Parkinson's disease who told their neurologists they were gambling too much, or had a family member say they were acting out of character.
After hearing reports that a class of drugs called dopamine agonists appeared to be linked to compulsive behaviour, the neurologists began tapering their patients off the medications.
"They began to hear back from the patients that this created a dramatic resolution of their symptoms," Dodd said Monday from Rochester.
Dopamine agonists work on receptors in the brain to boost levels of dopamine, a chemical that is diminished in people with Parkinson's disease.
These receptors are clustered in the limbic system, "which has a lot to do with a person's emotional behaviour and mood and internal reward system," Dodd said.
"These are tragic cases," she said, noting that the clergyman drove by a casino for many years, stopping in "every five years or so and maybe lost $20."
"Then he began to have to go there all the time, every day, and losing quite bit of money, keeping this secret from his wife. So there were very devastating character difficulties and moral character difficulties that he was having."
Patients weren't affected by just compulsive gambling. About half those involved in the 2002-2004 study reported sudden addictions to food, alcohol or sex.
"At least in a couple of cases, spouses stated that the patients became very hypersexual, to the point of chasing the spouse around the house seeking out sex."
Dodd stressed that the side-effect is rare: one study of more than 500 patients estimated 1.5 per cent developed addictive behaviours.
"The main thing I want people to realize is that this still is a very unusual occurrence, that they don't need to be panicked and discontinue their medication, because these are still really good medications for their disease process."
Among the dopamine agonists, Mirapex (pramipexole) appears to have the strongest effect.
In Canada, a proposed class-action lawsuit filed against Canadian distributor Boehringer Ingelheim, its U.S. counterpart and Pfizer Inc. is seeking $3 million per claimant over gambling addictions allegedly linked to the drug.
Darcy Merkur of the Toronto law firm Thomson Rogers, which filed the suit in May on behalf of representative plaintiff Gerard Schick of Midland, Ont., said that so far 58 plaintiffs from across Canada have sought to join.
"The study's consistent with other studies we have seen that link dopamine agonists to compulsive behaviour, in particular to compulsive gambling," said Merkur. "The link is definitely there and the fact that dopamine receptors have this propensity is something that we say ought to have been known to the manufacturers a long time ago."
But the manufacturer and distributors of the drug say there's no scientific evidence that Mirapex causes the problem.
A statement from Burlington, Ont.-based Boehringer Ingelheim (Canada) says some recent research has suggested that pathological gambling may be both part of Parkinson's itself and a side-effect of drugs to treat the disease, including all dopamine agonists and levodopa, the standard therapy.
Even so, the company has updated the labelling of Mirapex to advise doctors and patients about the potential impact.
Peggy Yates, a spokeswoman for the Parkinson Society of Canada, declined comment on the Mayo study but said the organization "supports research to study the relationship between gambling and/or other compulsive behaviours associated with Parkinson's disease and/or medication."
She added: "There is not enough scientific evidence to conclude a direct link at this time."
Parkinson's disease is a progressive disorder that affects movement, muscle control and balance. The cause is unknown, but by the time symptoms develop, patients have lost up to 90 per cent of dopamine-producing cells in the brain.
healthandfitness.sympatic...t=&abc=abc
11/07/2005 6:58:00 PM
TORONTO (CP) - A clergyman who rarely visits a casino suddenly becomes a compulsive gambler and starts bleeding his bank account dry. Another man becomes so aroused that he chases his wife around the house demanding sex.
What do these two men have in common? They both developed addictive behaviours after taking a particular type of drug to treat Parkinson's disease, say researchers at the Mayo Clinic in Rochester, Minn.
And the study found that patients completely lost the compulsive behaviour after stopping the drug.
"One patient said it was like a light switch going off," said Dr. Leann Dodd, a Mayo Clinic psychiatrist and co-author of the study published in the Archives of Neurology.
The study reports on two women and nine men with Parkinson's disease who told their neurologists they were gambling too much, or had a family member say they were acting out of character.
After hearing reports that a class of drugs called dopamine agonists appeared to be linked to compulsive behaviour, the neurologists began tapering their patients off the medications.
"They began to hear back from the patients that this created a dramatic resolution of their symptoms," Dodd said Monday from Rochester.
Dopamine agonists work on receptors in the brain to boost levels of dopamine, a chemical that is diminished in people with Parkinson's disease.
These receptors are clustered in the limbic system, "which has a lot to do with a person's emotional behaviour and mood and internal reward system," Dodd said.
"These are tragic cases," she said, noting that the clergyman drove by a casino for many years, stopping in "every five years or so and maybe lost $20."
"Then he began to have to go there all the time, every day, and losing quite bit of money, keeping this secret from his wife. So there were very devastating character difficulties and moral character difficulties that he was having."
Patients weren't affected by just compulsive gambling. About half those involved in the 2002-2004 study reported sudden addictions to food, alcohol or sex.
"At least in a couple of cases, spouses stated that the patients became very hypersexual, to the point of chasing the spouse around the house seeking out sex."
Dodd stressed that the side-effect is rare: one study of more than 500 patients estimated 1.5 per cent developed addictive behaviours.
"The main thing I want people to realize is that this still is a very unusual occurrence, that they don't need to be panicked and discontinue their medication, because these are still really good medications for their disease process."
Among the dopamine agonists, Mirapex (pramipexole) appears to have the strongest effect.
In Canada, a proposed class-action lawsuit filed against Canadian distributor Boehringer Ingelheim, its U.S. counterpart and Pfizer Inc. is seeking $3 million per claimant over gambling addictions allegedly linked to the drug.
Darcy Merkur of the Toronto law firm Thomson Rogers, which filed the suit in May on behalf of representative plaintiff Gerard Schick of Midland, Ont., said that so far 58 plaintiffs from across Canada have sought to join.
"The study's consistent with other studies we have seen that link dopamine agonists to compulsive behaviour, in particular to compulsive gambling," said Merkur. "The link is definitely there and the fact that dopamine receptors have this propensity is something that we say ought to have been known to the manufacturers a long time ago."
But the manufacturer and distributors of the drug say there's no scientific evidence that Mirapex causes the problem.
A statement from Burlington, Ont.-based Boehringer Ingelheim (Canada) says some recent research has suggested that pathological gambling may be both part of Parkinson's itself and a side-effect of drugs to treat the disease, including all dopamine agonists and levodopa, the standard therapy.
Even so, the company has updated the labelling of Mirapex to advise doctors and patients about the potential impact.
Peggy Yates, a spokeswoman for the Parkinson Society of Canada, declined comment on the Mayo study but said the organization "supports research to study the relationship between gambling and/or other compulsive behaviours associated with Parkinson's disease and/or medication."
She added: "There is not enough scientific evidence to conclude a direct link at this time."
Parkinson's disease is a progressive disorder that affects movement, muscle control and balance. The cause is unknown, but by the time symptoms develop, patients have lost up to 90 per cent of dopamine-producing cells in the brain.
healthandfitness.sympatic...t=&abc=abc